Case Report 1 Case Report 2 Case Report 3 Case Report 4 Visit 0 TC (mg/dL) 243.2 280 204 255.5 LDL-C (mg/dL) 160.9 -* 138 177.5 HDL-C (mg/dL) 49.1 43 45 56.6 TG (mg/dL) 167.4 500 102 107.2 TC/HDL-C ratio 5 6.5 4.5 4.5 Visit Xn TC (mg/dL) 190.6 229 185 247.8 LDL-C (mg/dL) 112.9 -* 120 169.1 HDL-C (mg/dL) 55.7 41 52 63.3 TG (mg/dL) 111.6 611 66 77.1 TC/HDL-C ratio 3.4 5.6 3.6 3.9 *Out of rang due to hypertriglyceridemia

Table 1: Laboratory data on cholesterols and triglycerides at baseline (Visit 0) and post-treatment (Visit Xn). Case report 1, n = 5 (13 months interval); Case report 2, n = 8 (7 months interval); Case report 3, n = 16 (11 months interval); Case report 4, n = 15 (12 months interval). Atherosclerotic index values are shaded grey.