Figure 1: Angiotensin II concentration, NADPH oxidase activity, and superoxide production in sham and STZ-induced diabetic rats. Apocynin (a NADPH oxidase inhibitor, 100 µM) and tempol (a superoxide dismutase mimetic, 1 mM) were used to confirm the specificity of the measurement for NADPH oxidase and superoxide production respectively. Data are mean ± SE, n=6 rats in each group. *P<0.05 vs. sham rats; #p<0.05 vs. diabetes.