| |
Glargine
(n = 708) |
Detemir
(n = 298) |
Glargine versus detemir
P value |
| |
Baseline |
Follow-up |
Baseline |
Follow-up |
Baseline |
Follow-up |
| Insulin dose (IU) |
|
|
|
|
|
|
| n (%) |
629 (89) |
629 (89) |
254 (85) |
254 (85) |
0.11 |
0.11 |
| Mean (SD) |
31.2 (24.0) |
31.3 (22.6) |
32.0 (22.7) |
36.6 (24.8) |
0.68 |
<0.01 |
| HbA1c (%) |
|
|
|
|
|
|
| n (%) |
708 (100) |
708 (100) |
298 (100) |
298 (100) |
|
|
| Mean (SD) |
8.6 (1.4) |
7.7 (1.2) |
8.4 (1.4) |
7.9 (1.2) |
<0.05 |
<0.05 |
| Change from baseline, mean (SD) |
|
–0.9 (1.4) |
|
–0.4 (1.4) |
|
<0.001 |
| Patients with HbA1c < 7%, n (%) |
70 (!0) |
196 (28) |
35 (12) |
70 (23) |
0.38 |
0.17 |
| Fasting plasma glucose (mmol/L) |
|
|
|
|
|
|
| n (%) |
512 (72) |
458 (65) |
222 (74) |
171 (57) |
0.48 |
0.48 |
| Mean (SD) |
11.0 (3.9) |
8.6 (3.0) |
10.4 (3.5) |
8.6 (2.8) |
<0.05 |
<0.05 |
| Change from baseline, mean (SD) |
|
–2.6 (4.3) |
|
–1.8 (3.8) |
|
<0.05 |
|
