Mean mRNA Expression
(Mean ratio of treated over controla)
CYP1A2
CYP2B6
CYP3A4
1 mM Remogliflozin
1.1 ± 0.16
1.0 ± 0.057
0.84 ± 0.19
10 mM Remogliflozin
1.7 ± 1.4
1.4 ± 0.18
1.7 ± 0.26
100 mM Remogliflozin
1.6 ± 0.38
2.2 ± 0.72
5.0 ± 2.4
Prototypical Inducerb
110 ± 83
8.6 ± 1.2 (PB)
14 ± 2.8 (Rif)
50 ± 32
aControls are defined as 0.1% (v/v) DMSO; Values are expressed as a mean ± standard
deviation of 3 human hepatocyte preparations. The criterion for notable induction
is a response by the test compound that is greater than 20% of the response seen by
the prototypical inducer bPrototypical CYP Inducers include: 50 μM Omeprazole for CYP1A2; 200 μM Phenobarbital
(PB) for CYP2B6; 50 μM Rifampicin (Rif) for CYP3A4 and CYP2B6
Table 4: Induction of Cytochrome P450 mRNA by Remogliflozin in Human Hepatocytes.
