| Variable |
Thiamine Treatment |
Placebo |
| |
Baseline |
Therapy |
Washout |
Baseline |
Therapy |
Washout |
| Plasma thiamine (nM/l) |
10.6 (0.8–84.5) |
98.2 (2.6–294.5) c, f |
10.9 (3.6–22.7) i |
7.1 (1.1–31.3) |
7.1 (2.4–16.6) |
9.1 (4.2–16.3) |
| Urinary thiamine (µmol/24 h) |
1.63 (0.45–7.66) |
47.69 (0.40–182.79) c,f |
1.42 (0.10–9.72) i |
1.53 (0.67–4.46) |
1.71 (0.15–9.73) |
1.16 (0.00–5.44) |
| Urinary albumin Excretion (mg/24 h)(30-300 MAU) |
43.7 (33.0–120.9) |
30.1 (12.0–38.2)b,f |
20.9 (7.0–35.0)f,h |
50.9 (33–122) |
35.5 (6.4–82.0) |
30 (3.5–80.4)f |
| Thiamine clearance(ml/min) |
112 (8-819) |
273(3-789)d |
92(18-237)h |
189(26-955) |
149 (12-663) |
102(12-334)e |
| Plasma glucose (mg/dl)(>126) |
181.8±57.6 |
181.8±70.2 |
144±6.3d |
177.58±55.8 |
158.4±43.24 |
144±55.8d |
| Glycated HbAic% (>7 diabetes) |
9.2±1.3 |
9.0±1.8 |
7.8±1.6 e,h |
8.8±1.8 |
8.5±1.7 |
8.4±1.7 |
| Total cholesterol (mg/dl) 200- 299)(high) |
203.40±50.27 |
188.32 (100.15-
374.90) |
178.26
(127.22–278.42) |
185.22±40.98 |
171.30±64.19 |
215.39±76.7h |
| LDL-cholesterol (mg/dl) (130-159(borderline high) |
106.34±47.14 |
98.996±66.12 |
93.19±32.09a |
106.34±35.96 |
92.05±460.01 |
123.35±47.95g |
| VLDL(mg/dl)( 40-100(high) |
46.330±31.792 |
55.62±36.46b |
48.260± 30.62 |
31.30 ±16.339 |
36.425±17.24d |
38.760 ± 13.9 e |
| HDL-cholesterol (mg/dl)(F<50,M<40)increased risk of coronary artery disease |
49.88±13.53 |
41.76±14.30d |
44.47±9.28 |
47.95±10.44 |
37.50±8.89f |
52.97±21.65h |
| Triacylglycerol (mg/dl) (200-499 high), |
198.47 (53.4-
739.59) |
202.03 (81.66-
620.73) |
231.4(79.21-
736.03) |
134.39(72.98-
377.3) |
159.31 (56.07-
357.78)d |
175.33 (96.12-
396.94)d |
| BILIRUBIN(0.1-1mg/dl) |
0.550±0.244 |
0.470±0.194 e |
0.503±0.24 |
0.514±0.283 |
0.382±0.185g |
|
| ALP(U/L)20-160 |
103.30±33.48 |
102.85±33.25 |
91.10±24. 83 |
88.20±29.84 |
80.65±44.75 |
84.1±34.15 |
| ALT(U/L)30-65 |
360.05±10.49 |
31.15± 10.36 |
32.10±10.59 |
36.10±10.40 |
31.85±11.41 |
36.20±15.81 |
| AST(U/L)15-37 |
22.60±9.70 |
19.00 ± 7.21 |
22.15±9.36 |
21.65±7.70 |
15.95±8.80 d |
20.55±5.68 |
