Variable (Diabetic Range) Thiamine Treatment Placebo
  Baseline Therapy Washout Baseline Therapy Washout
S VCAM1 (ng/ml) 588±267 554 ± 224 481± 192d, g
P’<0.05;
P”<0.05
648±255 608 ± 178 600 ± 232
VWF (U/ml) 0.67  (0.07 – 5.18) 0.48 (0.01 – 2.95) 0.51 (0.071 – 1.97) 0.48 (0.01 – 4.35) 0.48 (0.01 – 4.41) 0.59 (0.01 – 1.61)
P AI1 (ng/ml) 5.40±1.017 5.36±0.99 5.35±1.26 5.91±1.688 6.14 ± 1.44 6. 84 ± 1.36
Plasma thiols nmol/μl 3.91±0.723 3.71 ± 0.72 3.69 ± 0.64 4.15 ± 0.86 4.01 ± 0.89 3.97 ± 0.85
Protein kinase C pg/μg 60 ± 15.30 30.26 ± 19.37 37.98 ± 18.66 76.65 ± 56.22 77.75 ±58.29 98.67 ±76.48
Table 4: Endothelial Dysfunction, Hemostasis, Oxidative Stress and Cellular Signalling Mediator Profile before and after three month thiamine treatment and after two month washout period.