| |
Cohort 1 |
Cohort 2 |
Cohort 3 |
| Baseline
characteristics
(Mean ± SD) |
DM(356) |
DNP (139) |
P
value |
DM (342)
|
DNP (133) |
P
value |
DM (207) |
DNP (81)
|
P value |
| Age (years) |
59.3 ± 6.2 |
60.0 ± 5.8 |
0.42 |
58.0 ± 5.2 |
57.4 ± 6.6 |
0.51 |
54.3 ± 7.3 |
53.6 ± 4.9 |
0.36 |
| Sex M/F (n) |
142/214
(40/60) |
57/82
(41/59) |
0.98 |
161/ 181
(47/53) |
64/69
(48/52) |
0.81 |
106/101
(51/49) |
40/41
(49/51) |
0.85 |
| Duration of
diabetes
(Years) |
14.9 ± 4.2 |
15.2 ± 4.8 |
0.61 |
16.2 ± 5.1 |
16.7 ± 3.9 |
0.39 |
15.0 ± 3.8 |
14.8 ± 3.6 |
0.55 |
| Duration of
HTN (years) |
8.3 ± 4.9 |
5.6 ± 3.6 |
<0.001 |
8.0 ± 4.9 |
5.4 ± 4.0 |
0.001 |
8.5 ± 4.4 |
5.5 ± 4.7 |
<0.001 |
| BMI (kg/m2)
|
24.1 ± 3.0 |
28.2 ± 3.3 |
0.001 |
25.7 ± 3.6 |
25.8 ± 4.0 |
0.59 |
25.1 ± 3.9 |
24.7 ± 4.0 |
0.21 |
| SBP (mm Hg) |
136.2 ± 14.6 |
146.3 ± 18.0 |
<0.001 |
130.2 ± 12.3 |
142.6 ± 15.2 |
0.001 |
128.9 ± 15.6 |
145.5 ± 18.0 |
0.001 |
| DBP (mm Hg) |
83.3 ± 7.6 |
88.9 ± 8.9
|
0.001 |
81.0 ± 7.4 |
81.5 ± 7.4 |
0.25 |
76.9 ± 10.2 |
84.6 ± 10.0 |
<0.001 |
| HbA1c (%) |
8.1 ± 2.3 |
8.9 ± 1.4 |
<0.001 |
8.2 ± 1.6 |
8.9 ± 2.0 |
0.002 |
8.2 ± 1.9 |
8.9 ± 1.6 |
<0.001 |
| S.creat
(mg/dl) |
1.18 ± 0.15 |
4.12 ± 2.01 |
<0.001 |
1.5 ± 0.3 |
4.0 ± 1.3 |
<0.001 |
1.0 ± 0.3 |
4.6 ± 1.2 |
<0.001 |
| eGFR (ml/min) |
98.4 ± 18.6 |
58.7 ± 33.7 |
0.002 |
98.3 ± 16.3 |
57.3 ± 35.5 |
0.003 |
98.6 ± 17.7 |
54.8 ± 18.0 |
0.002 |
| TC |
260.1 ± 42.3 |
255.3 ± 46.3 |
0.85 |
264.3 ± 40.6 |
253.6 ± 48.8 |
0.77 |
251.1 ± 44.0 |
255.9 ± 36.6 |
0.89 |
| TG (mg%) |
208.3 ± 41.2 |
204.6 ± 32.8 |
0.79 |
207.4 ± 40.2 |
204.3 ± 30.1 |
0.65 |
203.6 ± 42.3 |
207.7 ± 31.0 |
0.75 |
| HDL (mg%) |
61.3 ± 14.4 |
64.4 ± 14.0 |
0.46 |
62.1 ± 13.8 |
63.7 ± 11.8 |
0.35 |
61.7 ± 12.5 |
62.7 ± 13.5 |
0.71 |
| LDL-C ( mg/dl) |
98.6 ± 30.1 |
102.3 ± 41.6 |
0.66 |
97.6 ± 29.0 |
101.3 ± 27.7 |
0.36 |
97.1 ± 26.5 |
101.0 ± 26.3 |
0.65 |
M: Male; F: Female; BMI: Body Mass Index; HTN: Hypertension; SBP: Systolic Blood Pressure; DBP: Diastolic Blood Pressure; S.creat: Serum Creatinine; eGFR:
Estimated Glomerular Filtration Rate by MDRD Formula; TC: Total Cholesterol; TG: Triglyceride; LDL-C: Low Density Lipoprotein Cholesterol; HDL-C: High Density
Lipoprotein Cholesterol (p<0.05 is significant).
*P value is after adjustment for multivariate regression analysis. Values are mean ± SD; unless indicated otherwise |
