| |
Cohort 1 |
Cohort 2 |
Cohort 3 |
| Haplotypea |
DNP (139) |
DM(356) |
OR (95%CI) P |
DNP (133)
|
DM (342) |
OR (95%CI) P |
DNP (81) |
DM (207) |
OR (95%CI) P |
| T-b-G |
17 (0.12) |
46 (0.13) |
Reference |
15 (0.11) |
44 (0.13) |
Reference |
10 (0.12) |
29 (0.14) |
Reference |
| T-b-T |
18 (0.14) |
53 (0.15) |
1.09 (0.82-1.55) 0.88 |
16 (0.12) |
48 (0.14) |
0.92 (0.70-1.32) 0.88 |
11 (0.14) |
33 (0.16) |
0.99 (0.68-1.36) 0.22 |
| C-b-G |
13 (0.09) |
39 (0.11) |
1.23 (0.99-1.59) 0.21 |
15 (0.11) |
44 (0.13) |
1.13 (1.02-1.80) 0.12 |
8 (0.10) |
25 (0.12) |
1.25 (0.92-1.77) 0.31 |
| T-a-G |
13 (0.09) |
39 (0.11) |
0.69(0.30-1.37) 0.55 |
13 (0.10) |
41 (0.12) |
1.22 (0.79-1.54) 0.91 |
8 (0.10) |
27 (0.13) |
0.93 (0.55-1.34) 0.77 |
| C-b-T |
22 (0.16) |
61 (0.17) |
0.69 (0.35-1.44) 0.67 |
21 (0.17) |
65 (0.19) |
0.79 (0.44-1.14) 0.37 |
12 (0.15) |
35 (0.17) |
0.77 (0.42-1.11) 0.45 |
| T-a-T |
24 (0.17) |
68 (0.19) |
1.12 (0.88-1.81) 0.13 |
23 (0.17) |
58 (0.17) |
1.55 (1.21-1.92) 0.12 |
13 (0.16) |
38 (0.18) |
0.99 (0.59-1.55) 1.02 |
| C-a-G* |
17 (0.12) |
25 (0.07) |
1.55 (1.22-2.80) 0.01 |
15 (0.11) |
21 (0.06) |
1.37 (1.20-2.94) 0.01 |
10 (0.12) |
10 (0.05) |
1.65 (1.42-2.91) 0.01 |
| C-a-T* |
15 (0.11) |
25 (0.07) |
1.71 (1.31-2.96) 0.008 |
15 (0.11) |
21 (0.06) |
1.71 (1.47-2.98) 0.009 |
9 (0.11) |
10 (0.05) |
1.77 (1.57-2.94) 0.007 |
aOrder of SNPs in eNOS haplotypes: T-786C, a 27VNTR b and G894T. *P<0.05 |
