Cohort 1 Cohort 2   Cohort 3       Variant 1 Variant 2 D’ LOD r2 Variant 1 Variant 2 D’ LOD r2 Variant 1 Variant 2 D’ LOD r2 T-786C 27VNTR 0.02 0.04 0.00 T-786C 27VNTR 0.03 0.06 0.01 T-786C 27VNTR 0.02 0.07 0.00 T-786C G894T 0.10 0.14 0.01 T-786C G894T 0.09 0.22 0.01 T-786C G894T 0.08 0.20 0.01 27VNTR G894T 0.03 0.04 0.00 27VNTR G894T 0.02 0.03 0.00 27VNTR G894T 0.02 0.02 0.01

Table 6: Measures of LD (D’, LOD, and r2), observed as a pair-wise comparison for the three polymorphisms of the eNOS gene.