Diabetic Non-diabetic
      p-values       p-values
EBGS (N=479) LIPUS (N=183) No-stim (N=742) EBGS vs. No- stim LIPUS vs. No- stim EBGS vs. LIPUS EBGS (N=2951) LIPUS (N=1251) No-stim (N=6022) EBGS vs. No- stim LIPUS vs. No- stim EBGS vs. LIPUS
% % % % % %
Age 1.7 1.1 1.8 <0.01 0.11 0.51 11.4 10.5 16.0 <0.01 <0.01 0.48
18–24            
25–34 3.1 1.1 2.0       10.2 9.3 11.5      
35–44 9.4 10.9 9.6       18.7 17.7 17.7      
45–54 35.7 33.3 24.5       30.9 31.6 28.3      
55–64 50.1 53.6 62.1       28.7 30.9 26.4      
Gender 42.2 47.5 47.0 0.10 0.90 0.21 39.9 39.6 49.8 <0.01 <0.01 0.89
Male            
Female 57.8 52.5 53.0       60.1 60.4 50.2      
Insurance plan type* 2.7 0.5 5.5 0.11 0.10 0.12 3.1 2.4 3.7 0.13 0.02 0.07
Comprehensive            
EPO 0.6 0.5 0.7       0.4 0.6 0.4      
HMO 17.3 11.5 13.5       14.2 13.7 15.0      
POS 8.1 8.2 6.9       10.2 10.2 8.9      
PPO 67.0 72.7 69.5       65.5 68.9 66.9      
POS w/ capitation† 0.6 0.5 0.4       0.7 0.2 0.6      
CDHP 0.8 2.7 1.5       2.8 1.8 2.2      
Missing/unknown 2.7 3.3 2.0       3.0 2.2 2.3      
U.S. Region 12.1 10.4 9.3 <0.01 0.01 0.10 14.3 9.0 9.5 <0.01 <0.01 <0.01
Northeast            
NorthCentral 22.5 26.2 31.8       22.4 20.5 28.4      
South 47.2 52.5 42.3       42.5 51.4 40.4      
West 15.2 7.7 15.2       18.7 16.7 19.9      
Unknown 2.9 3.3 1.3       2.0 2.5 1.9      
                         
Charlson comorbidity index‡ 63.9 61.2 57.5 0.03 0.37 0.52       0.01 0.02 0.80
CCI = 2       4.6 4.1 4.3      
CCI >= 3 36.1 38.8 42.5       2.6 2.7 2.8      
Fracture-related Comorbidities 100.0 100.0 100.0                  
Diabetes NA NA NA 0.0 0.0 0.0 NA NA NA
Osteoporosis 5.4 6.0 5.3 0.90 0.69 0.77 5.0 4.4 3.9 0.01 0.37 0.42
Malnutrition 0.0 1.1 0.8 0.05 0.71 0.02 0.1 0.2 0.2 0.18 0.62 0.62
Anemia 15.5 16.4 18.5 0.17 0.51 0.77 5.4 7.3 6.0 0.28 0.09 0.02
Smoking 0.0 0.6 0.3 0.26 0.56 0.11 0.2 0.3 0.4 0.37 0.87 0.63
Excessive alcohol drinking 0.8 0.0 0.9 0.84 0.19 0.21 0.8 0.4 0.8 0.80 0.11 0.17
Received chemotherapy 4.2 3.3 3.2 0.39 0.98 0.60 2.0 3.0 2.0 0.90 0.03 0.06
Received steroid 22.1 24.0 22.0 0.95 0.55 0.60 18.5 21.1 18.1 0.69 0.01 0.05
Received NSAIDs 27.6 27.3 23.7 0.13 0.31 0.95 27.4 25.6 23.0 <0.01 0.05 0.23
OADs and insulin use       0.03 0.57 0.03            
Neither 40.7 51.4 47.2                  
Insulin only 15.7 10.4 10.8                  
OADs only 30.9 23.5 28.4                  
Both insulin and OADs 12.7 14.8 13.6                  
*Acronyms for Insurance Plan Types include: Exclusive Provider Organization (EPO), Health Maintenance Organization (HMO), Point of Service (POS), Preferred Provider Organization (PPO) and Consumer-Directed Health Plan (CDHP)
†Capitation pays a physician or group of physicians a set amount for each enrolled person assigned to them, per period of time, whether or not that person seeks care
‡The Charlson Comorbidity Index (CCI) predicts the ten-year mortality rate for individuals diagnosed with a range of co-morbid conditions. Each comorbid condition is assigned a score (1,2,3, or 6) relative to the mortality risk associated with the condition. Higher scores indicate a higher mortality risk. CCI =2 includes hemiplegia, paraplegia, moderate to severe renal disease, diabetes, diabetes with chronic complications, any malignancy, leukemia, lymphoma, cellulitis, and skin ulcers. CCI=3 includes moderate to severe liver disease, AIDS, and metastatic solid tumors
Table 1: Demographics and comorbidities for the different treatment cohorts among diabetic and non-diabetic patients.