Study Group MAF General Association HWE p Binary logistic regression Group MAF X2 p OR (95 % CI) Additive Dominant Recessive p OR (95 % CI) p OR (95 % CI) p OR (95 % CI) Total study Samples 0.379 Aff 0.39 0.597 0.439 1.139 (0.818 - 1.587) 0.241 0.44 1.14 0.08 1.51 0.35 0.73 U Aff 0.36 0.072 0.82 - 1.59 0.96 - 2.41 0.39 - 1.39 T2DM & CON 0.379 Aff 0.37 0.039 0.843 1.038 (0.716 - 1.506) 0.823 0.85 1.04 0.21 1.39 0.16 0.58 U Aff 0.36 0.072 0.72 -1.49 0.83 - 2.34 0.27 -1.24 T2DNH & CON 0.386 Aff 0.42 1.615 0.204 1.3 (0.87 - 1.95) 0.823 0.22 1.28 0.07 1.72 0.96 0.98 U Aff 0.36 0.072 0.86 -1.88 0.96 -3.09 0.46 -2.07 MAF: Minor Allele Frequency; Aff = Affected; U Aff: Un-affected

Table 5: Summary statistical analysis of SNP (-344 C >T; rs1799998) of CYP11B2 gene by General association, HWE and binary logistic regression.