Reference Sex (n) Mean Age Mean BMI Study period Dietary protocol Exercise protocol Exercise Attendance
Villareal et al. [36] F (33) M (21) 70 37 12 mo. 500-750 kcal.day-1 deficit^ 1g protein.kg-1 BW   3 × 90 min.wk-1 supervised RT+AT.   83%
Goodpaster et al. [33] F+M (117) 47 44 6 mo. 1,200-2,100 kcal.day-1* 50-55/20-25/ 20-30 5 × 60 min.wk-1 unsupervised AT 20% increase in daily steps. 37 min.wk-1 increase in vigorous exercise.
Frimel et al. [35] F (18) M (12) 70 37 6 mo. 750 kcal.day-1 deficit^ 50/20/30 3 × 90 min.wk-1 supervised RT+AT   100%
Wadden et al. [34] F (120) 41 36 48wks 900 kcal.day-1 intake increasing to 1,500 kcal.day-1 from week 20. 55-60/12-15/15-30 AT-3 × 40 min.wk supervised or unsupervised AT. RT-3 × 40 min.wk-1, (1-2 sets x 10-14 reps of 11 exercises) supervised RT. CT- 3 × 40 min supervised or unsupervised AT + RT. 84-92% (wk1-8) 68.7% (wk 9-24) 56.9% (wk 25-40)
Wycherley et al. [37] F+M (59) 51 36. 4 mo. 1,400-1,600 kcal.day-1# 43/33/22 3 × 45 min.wk-1, (2 × 8-12 of 8 exercises) supervised RT 93%
^energy deficit calculated individually based on food diaries or indirect calorimetry to achieve specified weight loss in the set period; *energy intake calculated on initial weight for 12 month weight loss of 8-10%. #energy intake calculated on initial body weight to achieve moderate rate of weight loss; macronutrient composition (carbohydrate%/ protein%/fat%); RT: Resistance Training; AT: Aerobic Training; CT: Combined Aerobic and Resistance Training
Table 1: Study characteristics.