Groups (n=6)

  Serum Glucose Level (mg/dl)

  0 day

  7th day

  14th day

  21st day

  1.

  Normal Control

  85.43  ±  12.48

  86.19 ± 17.19

  81.74 ± 20.11

  89.76*** ± 2.63

  2.

  Positive Control (DM)

  348.23  ±  14.4

  363.48 ± 12.1

  372.31 ± 4.3

  379.20 ± 21.3

  3.

  DM + Pioglitazone

  332.17 ± 29.1

  202.31 ± 9.3

  143.21 ± 10.4

  91.34*** ± 6.93

  4.

  DM + Spirulina

  338.14 ± 7.9

  302 ± 9.36

  289.17 ± 21.2

  342.16** ±  24.18

  5.

  DM + Pioglitazone+ Spirulina

  320.78 ± 11.29

  221.77 ± 14.9

  173.11 ± 12.0

  75.70*** ± 3.4

Values are given as mean ± SEM for groups of six animals each
Normal group (Normal saline)
Diabetic control group (Dexamethasone)
***Values are extremely significant on 21st day at ***p< 0.0001(Tukey t-test). Diabetic control group were compared with normal group. Spirulina and Pioglitazone with
spirulina groups were compared with diabetic control
Table 2: Effect of Pioglitazone and Spirulina on Serum Glucose level at 21st day in Insulin Resistant Rat Model.