Vehicle Compound 1 P value    Plasma Metabolic Parameters Glucose 323.4 ± 92.8 205.75 ± 65.7 0.06 TG 123.6398 ± 44.8 63.1788 ± 8.9 0.03 LDL 35.98 ± 2.71 23.67 ± 4.25 0.008 HDL 155.87 ± 6.52 176.94 ± 21.19 0.0001 Insulin 17.67 ± 1.9 12.74 ± 1.5 0.004

Table 1: Compound 1 improves plasma metabolic parameters in ob/ob mice Plasma glucose (mg/dL) , insulin (ng/ml), triglycerides (TG) mg/dL, Low Density Lipoprotein (LDL) (mg/dL), High Density Lipoprotein (HDL) (mg/dL) measurements were in 14 week old ob/ob mice following treatment with vehicle or compound 1 for 4 weeks. Mean ± SD are reported. N=8 animals per group