| |
|
Group n (%) |
|
Group n (%) |
|
| SNP |
Genotype |
Responder |
Non-responder |
Allele |
Responder |
Non-responder |
P value |
| g.-234A/C |
A/A |
16 |
(45.7) |
8 |
(61.5) |
A |
50 |
(71.4) |
20 |
(76.9) |
0.590 |
| (rs13015258) |
A/C |
18 |
(51.4) |
4 |
(30.8) |
C |
20 |
(28.6) |
6 |
(23.1) |
|
| |
C/C |
1 |
(2.9) |
1 |
(7.7) |
|
|
|
|
|
|
| IVS8-128A/G |
G/G |
31 |
(88.6) |
11 |
(84.6) |
G |
66 |
(94.3) |
24 |
(92.3) |
0.661 |
| (rs17848920) |
G/A |
4 |
(11.4) |
2 |
(15.4) |
A |
4 |
(5.7) |
2 |
(7.7) |
|
| IVS8+46C/T |
C/C |
18 |
(51.4) |
5 |
(38.5) |
C |
51 |
(72.9) |
17 |
(65.4) |
0.474 |
| (rs10930040) |
C/T |
15 |
(42.9) |
7 |
(53.8) |
T |
19 |
(27.1) |
9 |
(34.6) |
|
| |
T/T |
2 |
(5.7) |
1 |
(7.7) |
|
|
|
|
|
|
| IVS11-143A/G* |
G/G |
20 |
(57.1) |
5 |
(38.5) |
G |
51 |
(72.9) |
17 |
(65.4) |
0.474 |
| (rs2302873) |
G/A |
11 |
(31.4) |
7 |
(53.8) |
A |
19 |
(27.1) |
9 |
(34.6) |
|
| |
A/A |
4 |
(11.4) |
1 |
(7.7) |
|
|
|
|
|
|
| G645G |
C/C |
25 |
(73.5) |
12 |
(92.3) |
C |
59 |
(86.8) |
25 |
(96.2) |
0.275 |
| (rs17848910) |
C/T |
9 |
(26.5) |
1 |
(7.7) |
T |
9 |
(13.1) |
1 |
(3.8) |
|
| IVS22+4C/T |
T/T |
31 |
(91.2) |
10 |
(76.9) |
T |
65 |
(95.6) |
23 |
(88.5) |
0.342 |
| (rs2268891) |
T/C |
3 |
(8.8) |
3 |
(23.1) |
C |
3 |
(4.4) |
3 |
(11.5) |
|
Nucleotide location number of SNP was assigned according to the DPP4 mRNA sequence (GenBank accession number: NM_001935.3). In comparison between alleles,
P values were obtained by using Chi-square test or Fisher’s exact test (expected cell value < 5).
Abbreviations: IVS: Intervening Sequence; SNP: Single Nucleotide Polymorphism. * Linkage with rs10930040 |
