Inflammatory Mediator |
Level |
Tissue |
Model |
Reference |
TLR4 |
increase |
monocyte |
Type 1 patients |
Devaraj et al. 2008 |
|
|
|
|
|
TLR2 |
increase |
monocyte |
Type 1 patients |
Devaraj et al. 2008 |
|
|
|
|
|
MCP1 |
increase |
peripheral blood |
Type 2 patients |
Nomura et al. 2000 |
|
increase |
serum |
Type 1 patients (multiple complications) |
Guan et al. 2011 |
|
increase |
plasma and adipose |
ob/ob diabetic mice |
Sartipy and Loskutoff 2003 |
|
|
|
|
|
RANTES |
increase |
peripheral blood |
Type 2 diabetic patients |
Nomura et al. 2000 |
|
|
|
|
|
TNF-α |
increase |
plasma and macrophage |
DN (painful compared to painless) |
Purwata et al. 2011 |
|
decrease |
Lumbar DRG |
STZ-induced rat model |
Saleh et al. 2011 |
|
increase |
serum |
STZ-induced mouse model |
Yamakawa et al. 2011 |
|
increase |
DRG (mRNA) |
STZ-induced mouse model |
Yamakawa et al. 2011 |
|
increase |
serum |
DN patients compared to diabetic-no neuropathy |
Doupis et al. 2009 |
|
increase |
sciatic nerve |
STZ-induced mouse model |
Kellogg et al. 2007 |
|
increase |
sciatic nerve |
STZ-induced rat model |
Kellogg et al. 2007 |
|
increase |
serum |
STZ-induced mouse model |
Sharma et al .2007 |
|
increase |
serum |
STZ-induced rat model |
Qiang et al. 1998a,b |
|
increase |
serum |
STZ-induced mouse model |
Sharma et al .2006 |
|
|
|
|
|
COX-2 |
increase |
sciatic nerve |
STZ-induced rat model |
Kellogg et al. 2007 |
|
increase |
sciatic nerve and DRG |
STZ-induced mouse model |
Kellogg et al. 2007 |
|
increase |
sciatic nerve |
STZ-induced rat model |
Pop-Busui et al. 2002 |
|
|
|
|
|
IL-6 |
increase |
sciatic nerve (mRNA) |
STZ-induced mouse model |
Bierhaus et al. 2004 |
|
increase |
sural nerve |
DN patients compared to control |
Bierhaus et al. 2004 |
|
increase |
DRG (mRNA) |
STZ-induced mouse model |
Yamakawa et al. 2011 |
|
|
|
|
|
IL-1α |
increase |
monocyte |
Type 1 and 2 patients compared to controls |
Giulietti et al. 2007 |
|
|
|
|
|
IL-8 |
increase |
monocyte |
Type-2 patients compared to control |
Giulietti et al. 2007 |
|
|
|
|
|
NF-κB |
increase |
DRG, sciatic, sural nerve |
STZ-induced mouse model |
Toth et al. 2008 |
|
increase |
sural nerve |
DN patients compared to control |
Bierhaus et al. 2004 |
|
increase |
sciatic nerve |
STZ-induced mouse model |
Bierhaus et al. 2004 |
