Animals

Strains

Model

Regimen

Age

Sex

Nociceptive behavorial test

Reported pain symptoms (hyperalgesia/allodynia)

Nerve Conduction

References

Rat

ZDF

Bio-Breeding Zuker Diabetic Rat (BBDZR)

Rat chow

8 months

Male

Plantar test

Thermal hyperalgesia

Decreased

Kamiya H et al. 2005

Rat

Wistar

Goto-Kakizaki

Rat chow

7 to 32 weeks

Male and female

Tail-Flick

Thermal hypoalgesia

Not done

Ueta K et al. 2005

Rat

Wistar

Goto-Kakizaki

Rat chow

6 weeks

Male

None

None

Decreased

Kitahara Y et al. 2002

Rat

Wistar

Goto-Kakizaki

Rat chow

18 months

Male

None

None

Decreased

Murakawa Y et al. 2002

Rat

Wistar

Goto-Kakizaki

Rat chow

10 weeks

Male

TailFlick

Thermal hypoalgesia

Not done

Liepinsh E et al. 2009

Rat

Long Evans

Otsuka Long-Evans Tokushima Fatty (OLETF)

30 % Sucrose in drinking water

30 weeks

Male

None

None

Decreased

Nakamura J et al. 1997

Rat

Long Evans

Otsuka Long-Evans Tokushima Fatty (OLETF)

Sucrose feed

2 months

Male

Tail Flickand Tail Pressure Test

Mechanical and thermal hypoalgesia

Decreased

Kamenov Z et al. 2006

Rat

SpragueDawley

STZ-induced type II Diabetes*

Standard rat diet supplemented with 10% sucrose, 10% lard, 2% cholesterol and 0,2% cholic acid + STZ 30 mg/kg

4 weeks after induction of diabetes

Male

Radian Test

Thermal hypoalgesia

Decreased

Xiu-ying Yang et al. 2011

Rat

ZDF

ZuckerDiabeticFatty

Rat chow

8 weeks

Male

von Frey hairs Test and Plantar Test

Tactile allodynia

Decreased

Brussee V et al. 2008

Rat

ZDF

ZuckerDiabeticFatty

Rat chow

7 weeks

Male

von Frey hairs Test

Tactile allodynia

Not done

Otto KJ et al. 2011

Rat

ZDF

ZuckerDiabeticFatty

Rat chow

6 to 10 weeks

Male

Randal-Selitto

Mechanical hyperalgesia

Not done

Romanovsky D et al. 2008

Rat

ZDF

ZuckerDiabeticFatty

Rat chow

6 weeks after diagnostic of hyperglycemia

Male

von Frey and thermal stimulation

Thermal hyperalgesia, Tactile allodynia.

Decreased

Li F et al. 2006

Rat

ZDF

ZuckerDiabeticFatty

Rat chow

15 weeks

Male

None

None

Decreased

Shimoshige Y et al. 2000

Rat

ZDF

ZuckerDiabeticFatty

Rat chow

8 to 36 weeks

Male and female

Tail Flick, Randall-Selitto

Thermal hypoalgesia followed by apersistent thermal hyperalgesia and tardive mechanical hyperalgesia.

Not done

Sugimoto K et al. 2008

*Developp by Srinivasan K et al. (PharmacolRes. 2005)

 

 

 

 

 

Table 1: Rat models used in T2D-induced neuropathy.