Animals

Strains

Model

Regimen

Age

Sex

Nociceptive behavorial test

Reported pain symptoms (hyperalgesia/allodynia)

Nerve Conduction

References

Mice

C57Bl6/J

High Fructose Diet

D12328, 10,5 kcal% fat, and D12330, 58kcal% fat with corn starch

16 weeks of diet

Male

von Frey hairs test, Tail Flick

Thermal and mechanical hypoalgesia, and tactile allodynia

Decreased

Watcho P et al. 2010

Mice

C57Bl6/J

High Fructose Diet

D12328, 10,5 kcal% fat, and D12330, 58kcal% fat with corn starch

16 weeks of diet

Female

von Frey hairs test, Tail Flick

Thermal hypoalgesia, Tactile allodynia.

Decreased

Obrosova IG et al. 2007

Mice

C57Bl6/J

High Fructose Diet

D12328, 10,5 kcal% fat, and D12330, 58kcal% fat with corn starch

16 weeks of diet

Female

von Frey hairs test, Tail Flick

Thermal hypoalgesia, Tactile allodynia.

Decreased

Stavniichuk R et al. 2010

Mice

C57/BL6

high-fat (45% kcal %fat) diet

45% kcal %fat diet D12451i

34 weeks

Male

Radian test

Thermal hypoalgesia

Decreased

Vincent AM 2009

Mice

C57BLKS/J

Leptin receptor-deficient db/db mice

Micechow

10-12 weeks

Male

Beam walk, Footprinting, Grid walk, Rotarod

None

Decreased

Muller KA et al.  2009

Mice

BKS.Cg-m+/+Leprdb/J

Leptin receptor-deficient db/db mice

Micechow

24 weeks

Male

Hind paw withdrawal time and Tail Flick

Thermal hypoalgesia

Decreased

Pande M et al.  2011

Mice

C57BLKS

Leptin receptor-deficient db/db mice

Micechow

?

Male

von Frey hairs test

Mechanical hyperalgesia

Not done

Cheng HT et al.  2010

Mice

C57BLKS

Leptin receptor-deficient db/db mice

Micechow

10 weeks

?

von Frey hairs test

Mechanical allodynia

Not done

Liao YH et al. 2010

Mice

BKS.Cg-m+/+Leprdb/J

Leptin receptor-deficient db/db mice

Micechow

9 to 16 weeks

Male

von Frey hairs test, Dynamic plantar aesthesiometer, Plantar test, Formalin

Mechanical hyperalgesia, hypoesthesia in second phase of formalin test

Not done

Wright DE et al. 2007

Mice

C57BLKS/J

Leptin receptor-deficient db/db mice

Micechow

1 to 5 month

Male

von Frey hairs test

Mechanicalhypersensitivity

Not done

Ren YS et al. 2012

Mice

C57Bl6/J 

Leptin-deficient ob/ob mice

Micechow

8 weeks

?

von Frey hairs test, Radian test, Hot plate test (55°C)

Thermal hypoalgesia, Tactile allodynia.

Decreased

Vareniuk I et al.  2007

Mice

C57Bl6/J

Leptin-deficient ob/ob mice

Micechow

6 weeks

?

von Frey hairs test, Radian test

Thermal hypoalgesia, Tactile allodynia.

Decreased

Drel VR et al.  2006

Mice

C57BL6

Leptin-deficient ob/ob mice and Leptin receptor-deficient db/db mice

Micechow

4 months

Male and female

None

None

Not done

Nowicki M et al. 2012

Mice

CD1

Stress-induced type 2 Diabetes

Micechow

30 days

Male

TailFlick

Thermal hypoalgesia

Not done

Loizzo S et al.  2010

Mice

ddY-SPF

Tsumura, Suzuki, Obese Diabetes (TSOD)

Micechow

6 and 12 months

Male

Tail pressure test (Analgesymeter)

Mechanical hyperalgesia

Not done

Iizuka S et al. 2005

Table 2: Mice models used in T2D-induced neuropathy.