Time(hr) PIO conc (µg/mL) PIO + CURC(SDI)conc(µg/mL) PIO + CURC(MDI)conc(µg/mL)
0 0 ± 0 0 ± 0 0 ± 0
0.5 3.32214 ± 0.40012 3.15203 ± 0.22419 3.57120 ± 0.24511*
1 2.76383 ± 0.57146 5.06782 ± 0.92310*** 5.91402 ± 0.54653***
2 4.37565 ± 0.74325 5.23959 ± 0.87716*** 5.99852 ± 0.39739**
4 3.09569 ± 0.51140 3.43299 ± 0.29897 3.63482 ± 0.44771
8 1.28946 ± 0.61786 0.69315 ± 0.57193 0.11295 ± 0.78430
24 0.36342 ± 0.34822 0.24298 ± 0.48015 0.25619 ± 0.35176
Mean +/- SD, ***significant at p<0.001, **significant at p<0.01, *significant at p<0.05 compared to pioglitazone control;
SDI: Single Dose Interaction; MDI: Multiple Dose Interaction; PIO: Pioglitazone; CURC: Curcumin
Table 2: Mean serum concentration of pioglitazone in presence of curcumin (SDI and MDI) in diabetic rats.