| Time(hr) |
PIO conc (µg/mL) |
PIO + CURC(SDI)conc(µg/mL) |
PIO + CURC(MDI)conc(µg/mL) |
| 0 |
0 ± 0 |
0 ± 0 |
0 ± 0 |
| 0.5 |
3.32214 ± 0.40012 |
3.15203 ± 0.22419 |
3.57120 ± 0.24511* |
| 1 |
2.76383 ± 0.57146 |
5.06782 ± 0.92310*** |
5.91402 ± 0.54653*** |
| 2 |
4.37565 ± 0.74325 |
5.23959 ± 0.87716*** |
5.99852 ± 0.39739** |
| 4 |
3.09569 ± 0.51140 |
3.43299 ± 0.29897 |
3.63482 ± 0.44771 |
| 8 |
1.28946 ± 0.61786 |
0.69315 ± 0.57193 |
0.11295 ± 0.78430 |
| 24 |
0.36342 ± 0.34822 |
0.24298 ± 0.48015 |
0.25619 ± 0.35176 |
Mean +/- SD, ***significant at p<0.001, **significant at p<0.01, *significant at
p<0.05 compared to pioglitazone control;
SDI: Single Dose Interaction; MDI: Multiple Dose Interaction; PIO: Pioglitazone;
CURC: Curcumin |
