| Time(hr) |
PIO - conc (µg/mL) |
PIO + CURC(SDI)conc(µg/mL) |
PIO + CURC(MDI)conc(µg/mL) |
| 0 |
0 ± 0 |
0 ± 0 |
0 ± 0 |
| 0.5 |
3.90468 ± 0.31409 |
2.90990 ± 0.77831 |
1.65410 ± 0.78332 |
| 1 |
3.70254 ± 0.40765 |
4.73127 ± 0.25601 |
2.58540 ± 1.44478 |
| 2 |
4.15260 ± 0.50056 |
3.14920 ± 0.46717 |
3.68825 ± 0.42379 |
| 4 |
2.48083 ± 0.59884 |
4.38872 ± 0.54639 |
1.57314 ± 0.51843 |
| 8 |
0.65313 ± 0.48756 |
0.51782 ± 0.67227 |
2.19537 ± 0.71474 |
| 24 |
0.24025 ± 0.22673 |
0.19371 ± 0.30735 |
0.24579 ± 0.31364 |
Mean +/- SD, ***significant at p<0.001,**significant at p<0.01, *significant at p<0.05
compared to pioglitazone control
SDI: Single Dose Interaction; MDI: Multiple Dose Interaction; PIO: Pioglitazone;
CURC: Curcumin |
