Time(hr) PIO - conc (µg/mL) PIO + CURC(SDI)conc(µg/mL) PIO + CURC(MDI)conc(µg/mL)
0 0 ± 0 0 ± 0 0 ± 0
0.5 3.90468 ± 0.31409 2.90990 ± 0.77831 1.65410 ± 0.78332
1 3.70254 ± 0.40765 4.73127 ± 0.25601 2.58540 ± 1.44478
2 4.15260 ± 0.50056 3.14920 ± 0.46717 3.68825 ± 0.42379
4 2.48083 ± 0.59884 4.38872 ± 0.54639 1.57314 ± 0.51843
8 0.65313 ± 0.48756 0.51782 ± 0.67227 2.19537 ± 0.71474
24 0.24025 ± 0.22673 0.19371 ± 0.30735 0.24579 ± 0.31364
Mean +/- SD, ***significant at p<0.001,**significant at p<0.01, *significant at p<0.05 compared to pioglitazone control
SDI: Single Dose Interaction; MDI: Multiple Dose Interaction; PIO: Pioglitazone; CURC: Curcumin
Table 3: Mean serum concentration of pioglitazone and pioglitazone in presence of curcumin (SDI and MDI) in normal rats.