*indicates a significant difference from the corresponding value at 3 months of age within the same strain
#indicates a significant difference from the corresponding value at 6 months of age within the same strain
†indicates a significant difference from the corresponding value in GK rats
Figure 2: Temporal changes in mean arterial pressure (Panel A), renal blood flow (Panel B), glomerular filtration rate(Panel C) and plasma creatinine concentration (Panel D) in Goto-Kakizaki (GK)rats and the modified GK substrain susceptible to diabetic nephropathy (T2DN) rats during 3 to 18 months of age. Numbers in parentheses indicate the number of rats studied per group. Values are means ± S.E.