Effect or Relationship Coefficients of linear combination Core Number SMCV 95% confidence interval of SMCV c+- probability Strength Type
A: Drug A 1• 3 0.442 (0.072, 0.821) 0.671 Medium
B: Drug B 2• 3 -0.442 (-0.821, -0.072) 0.329 Medium
Average drug effect magnitude     0.442     Medium
C: Hour 4 •1 2 -2.968 (-3.733, -2.279) 0.001 Extra large
Extra large D: Hour 10 •2 2 1.028 (0.548, 1.529) 0.848 Large
Large E: Hour 16 •3 2 1.940 (1.377, 2.549) 0.974 Extra large
Average time effect magnitude     1.979     Extra large
F: Linear (-1, 0, 1, -1, 0, 1) 2 2.834 (2.162, 3.578) 0.998 Extra large
G: Quadratic (-1, 2, -1, -1, 2, -1) 2 1.028 (0.548, 1.529) 0.848 Large
Table 6: Contrast analysis using contrast variable for an illustrative example about safety assessment of Drugs A and B at hours 4, 10 and 16.