(GP1, GP2)

(GS1, GS2,GS3)

X  Statistic

(11, 12)

(11, 11 ,11)

X = 1

 

(11, 11, 12)

X = 0

 

(11, 12, 12)

X = 0

 

(12, 12, 12)

X = -1

(12, 12)

(11, 11 , 11)

X = 2

 

(11, 11 , 12)

X = 1

 

(11, 11 , 22)

X = 0

 

(11, 12 , 12)

X = 1 or 0

 

(11, 12 , 22)

X = 0

 

(11, 22 , 22)

X = 0

 

(12, 12 , 12)

X = 0

 

(12, 12 , 22)

X = -1 or 0

 

(12, 22 , 22)

X = -1

 

(22, 22 , 22)

X = -2

(22, 12)

(22, 22 , 22)

X = -1

 

(22, 22 , 12)

X = 0

 

(22, 12 , 12)

X = 0

 

(12, 12 , 12)

X = 1

Table 5: X Statistic in thenuclear family with three affected siblings