|
Measure |
|
Site with p ≤ 0.05 |
Total |
| (a) |
(b) |
(c) |
| with case #5 |
regardless #5 |
without case #5 |
| β-value |
809 (29.85%) |
1,282 (47.31%) |
619 (22.84%) |
2,710 |
| M-value |
592 (21.69%) |
1,523 (55.81%) |
614 (22.50%) |
2,729 |
| N-value |
361 (18.90%) |
1,147 (60.05%) |
402 (21.05%) |
1,910 |
The differentially methylated CpG sites have been identified by two-sample t-test, with p ≤ 0.05 for 7 control samples and 7 case samples over 27,578 CpG sites. By including an outlying sample, case #5, the identified number of CpG sites is changed. Columns (a), (b) and (c) summarize the number of CpG sites identified to be differentially methylated under t-tests, with or without case #5: (a) t-tests identify corresponding sites only when case #5 is included; (b) t-test identify the sites regardless of inclusion of case #5; and (c) t-test identify the sites only when case #5 is excluded. The total column presents the number of identified CpG sites, with or without case #5 by three summary measures. |
