ML Estimates of Follow-Up Period Treatment Arms Size Mean Variance Year 1 Control 51 1.5294 1.3341 1.5294 -0.1344   s.c. IFN beta-1a 46 0.3696 0.5048 0.3696 1.1538   i.m. IFN beta-1a 46 1.1522 1.3319 1.1522 0.1420   GA 48 0.7917 0.7642 0.7917 -0.0853               Year 2 Control 51 2.9608 4.5584 2.9608 0.2559   s.c. IFN beta-1a 46 0.7174 0.7850 0.7174 0.0818   i.m. IFN beta-1a 47 1.6596 2.2294 1.6596 0.2326   GA 48 1.2917 1.4876 1.2917 0.1225

Table 2: Summary statistics and the maximum likelihood estimates of the model parameters for MRI cortical lesions data of example 1.