Follow-Up Period Comparison Groups Method Lower CI Upper CI Width Year 1 s.c. IFN beta-1a VS control NB 0.0964 0.3869 1.3901     NB* 0.1325 0.4408 1.2024     GEE 0.0999 0.3834 1.3449     GEE* 0.1344 0.4344 1.1732     Ratio 0.0983 0.3849 1.3645     Ratio* 0.1335 0.4372 1.1860   i.m. IFN beta-1a VS control NB 0.4886 1.0180 0.7340     NB* 0.5301 1.0705 0.7027     GEE 0.4880 1.0187 0.7360     GEE* 0.5297 1.0715 0.7045     Ratio 0.4851 1.0215 0.7446     Ratio* 0.5277 1.0755 0.7120   GA VS control NB 0.3286 0.7067 0.7658     NB* 0.3593 0.7458 0.7304     GEE 0.3256 0.7097 0.7792     GEE* 0.3572 0.7502 0.7421     Ratio 0.3236 0.7117 0.7882     Ratio* 0.3558 0.7531 0.7498 Year 2 s.c. IFN beta-1a VS control NB 0.1430 0.3416 0.8708     NB* 0.1608 0.3650 0.8196     GEE 0.1445 0.3401 0.8562     GEE* 0.1618 0.3628 0.8075     Ratio 0.1434 0.3412 0.8667     Ratio* 0.1611 0.3644 0.8162   i.m. IFN beta-1a VS control NB 0.3721 0.7489 0.6994     NB* 0.4005 0.7845 0.6722     GEE 0.3805 0.7405 0.6659     GEE* 0.4065 0.7728 0.6423     Ratio 0.3786 0.7424 0.6734     Ratio* 0.4052 0.7754 0.6491   GA VS control NB 0.2874 0.5851 0.7111     NB* 0.3101 0.6137 0.6826     GEE 0.2927 0.5798 0.6835     GEE* 0.3139 0.6062 0.6581     Ratio 0.2912 0.5813 0.6912     Ratio* 0.3129 0.6083 0.6649

Table 3: 95% confidence intervals of the with the confidence widths by the all six methods for MRI cortical lesions data of example 1.