ML Estimates of
Follow-Up Period Treatment Arms Size Mean Variance
Year 1 Placebo 827 0.2709 0.7619 0.2709 4.2018
  Beta-carotene 856 0.2979 0.6468 0.2979 4.2009
             
Year 2 Placebo 803 0.2403 0.4771 0.2403 3.5114
  Beta-carotene 827 0.2612 0.4571 0.2612 2.9188
             
Year 3 Placebo 776 0.2474 0.6071 0.2474 4.6972
  Beta-carotene 794 0.3154 1.2643 0.2859 6.0556
             
Year 4 Placebo 699 0.2332 0.6117 0.2332 5.6482
  Beta-carotene 688 0.3154 1.2643 0.3154 4.8770
             
Year 5 Placebo 419 0.2721 0.7153 0.2721 4.2656
  Beta-carotene 392 0.2985 0.8033 0.2985 3.5507
Table 4: Summary statistics and the maximum likelihood estimates of the model parameters for skin cancer data of example 2.