Log Relative Risk        Penetrance by age 70 Model BRCA1 (SE) BRCA2 (SE) BRCA1 (SE) BRCA2 (SE ) Independent 1.109 (0.357) 1.243 (0.325) 0.609 (0.116) 0.665 (0.109) Frailty 1.212 (0.189) 1.354 (0.173) 0.639 (0.067) 0.646 (0.063)

Table 5: Log relative risk and penetrance estimates of BRCA1 and BRCA2 genes.