Figure 3: Induction of LTP like activity in cultured hippocampal networks. A: Random network of hippocampal neurons at 14 DIV, B: Patterned network at 14 DIV were rows of electrodes are connected by thin vertical line/gap segments every 200 μm. C: Effect of ACPD on spike and burst rates before (black) and after treatment (grey bars). In both groups, addition of ACPD resulted in an overall increase in spike rates across electrodes and an increased rate of bursting (see statistical evaluation in the text).