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Figure 4: Biodistribution of platinum in various organs. Cisplatin and dendrimer-cisplatin complexes (G4 NH2 and Biotin G4 NH2) were administered intraperitoneally at 4 mg/kg and organs were isolated after 24 hrs of administration from animals euthanized by CO2. The organs were homogenized and treated with Conc. HNO3 and platinum was analyzed using ICP-MS. Results were compared using student“s t-test and p<0.05 was considered significant. |