Group Treatment Median Survival§ (Days) % Change in Lifespan † Maximum Survival (Days) 1 Control: intraperitoneal saline 15.5   25 2 Cisplatin (4 mg/kg): Intraperitoneally 1 X / Week X 4 28.5 83.87 32 3 G4 NH2 Cisplatin (4 mg/kg): Intraperitoneally 1 X / Week X 4 35 125.80 45 4 Biotin G4 NH2 Cisplatin (4 mg/kg): Intraperitoneally, 1 X / Week X 4 32.5 109.67 47 §-Median survival was calculated using Kaplan-Meier analysis. Log-rank test (Mantel-Cox test) indicated significant differences amongst all treatment groups. †-Percentage change in lifespan, calculated as: [(median survival time in treated animals/median survival time in controls)–1]×100. *-Statistical analyses were performed by Graph Pad Prism 5.0®, and evaluated for statistically significant differences by one-way ANOVA and F<0.05 was considered statistically significant. Percentage of survival was analyzed using Kaplan-Meier analysis and compared using the long-rank test.

Table 2: Statistical analysis of the results obtained from survival studies.