| Percentage of filamentation |
| Dose (J) |
Continuous |
2.5 Hz |
250 Hz |
2500 Hz |
| AB1157 |
| 0.13 |
1.0 ± 0.50 |
2.3 ± 0.58* |
1.0 ± 0.40 |
1.7 ± 0.48 |
| 0.52 |
2.0 ± 0.82* |
3.0 ± 1.00* |
1.7 ± 0.59 |
2.7 ± 0.55* |
| 1.04 |
5.0 ± 1.00* |
7.3 ± 1.58* |
7.0 ± 1.00* |
2.0 ± 0.37* |
| BW527 |
| 0.13 |
8.7 ± 1.15* |
8.0 ± 1.00* |
6.7 ± 1.10* |
6.0 ± 1.01 |
| 0.52 |
4.0 ± 1.00 |
4.4 ± 1.15 |
7.3 ± 0.59* |
4.7 ± 0.54 |
| 1.04 |
4.3 ± 0.53 |
5.0 ± 1.02 |
3.3 ± 0.56 |
4.6 ± 1.52 |
| BW9091 |
| 0.13 |
18.3 ± 1.25* |
14.0 ± 2.60 |
22.3 ± 2.64* |
11.3 ± 1.50 |
| 0.52 |
28.0 ± 2.65* |
18.3 ± 2.08* |
18.7 ± 1.53* |
19.0 ± 1.73* |
| 1.04 |
39.7 ± 2.52* |
30.7 ± 2.10* |
39.3 ± 2.11* |
15.3 ± 1.52* |
| BH20 |
| 0.13 |
6.0 ± 1.00* |
7.3 ± 1.15* |
7.0 ± 0.04* |
3.3 ± 0.59 |
| 0.52 |
6.3 ± 0.58* |
4.7 ± 0.60* |
6.3 ± 1.11* |
4.3 ± 1.20* |
| 1.04 |
9.7 ± 1.53* |
5.0 ± 1.10* |
8.3 ± 2.08* |
4.3 ± 1.50* |
| BW375 |
| 0.13 |
7.7 ± 2.08 |
11.7 ± 1.50* |
11.0 ± 1.73* |
19.0 ± 2.65* |
| 0.52 |
19.3 ± 2.10* |
19.7 ± 0.53* |
12.3 ± 3.06* |
19.0 ± 1.00* |
| 1.04 |
23.3 ± 1.43* |
22.7 ± 2.52* |
27.3 ± 2.50* |
23.0 ± 2.55* |
Controls: 0.2 ± 0.03 for AB1157, 4.7 ± 0.60 for BW527, 10.7 ± 2.08 for BW9091,
1.7 ± 0.58 for BH20, 6.7 ± 1.54 for BW375. (*) p<0.05 when compared with control
group. Error bars indicate the standard deviation of the mean for n=2 independent
experiments |
