Figure 2: The expression of collagen IV (a) and transepidermal water loss (TEWL) (b) in the dorsal skin of SPF and conventional NC/Nga mice. The mice subjected to strong exercise exhibited decreased expression of collagen IV in comparison with the no exercise mice, and the mice subjected to mild exercise showed increased expression in comparison to the no exercise mice. The data show one typical experiment from 10 animals. Scale bar = 100 μm. Strong exercise increased the TEWL in comparison to the mice not subjected to exercise, and mild exercise decreased the TEWL in comparison to the no exercise mice. The values are presented as the means ± SD from 10 animals.*P<0.05 in comparison to the no exercise SPF or conventional NC/ Nga mice.