| Treatment groups |
Drug name |
Total duration of convulsion (Sec) |
% change from control (Convulsive time) |
Mortality (%) |
Protection (%) |
Significance |
| I |
10% DMSO |
242.60 |
100 |
100 |
- |
- |
| II |
Zonisamide |
280.72 |
15.1 |
33.7 |
66.7 |
NS |
| III |
A-350619 |
216.54 |
11.2 |
83.3 |
16.7 |
NS |
| IV |
Methylene blue |
343.67 |
40.9 |
16.7 |
83.3 |
P<0.01 |
| V |
BRL50481 |
278.18 |
14.1 |
83.3 |
16.7 |
NS |
| VI |
A-350619 + BRL50481 |
235.67 |
3.40 |
50.0 |
50.0 |
NS |
| VII |
Methylene blue + BRL50481 |
340.72 |
39.7 |
16.7 |
83.3 |
P<0.01 |
The group of rats (n=6) were subjected to 150 mA (0.2 sec) electroshock and total convulsive time was estimated. A value of P<0.05 was considered significant Vs DMSO group, NS= P > 0.05. All the drugs were injected intraperitoneally. The drugs used were administered in the following doses. DMSO (3.5 ml/kg, i.p), zonisamide (35 mg/kg, i.p), A-350619 (100 µM/kg, i.p), methylene blue (50 mg/kg, i.p) and BRL50481 (1.4 mg/kg, i.p). (One way ANOVA followed by Dunnett’s test compared with DMSO treated rats).
|
