Figure 2: Time course of the analgesic effect observed after i.c.v. injection of SB366791 at 10 days after CCI. Intracerebroventricular (i.c.v.) injection of TRPV1 inhibitor SB366791 reversed the established mechanical allodynia (A) and thermal hyperalgesia (B) induced by CCI at 10 days after operation. The sham group is placd as a reference for the maximum possible effect. The MWT and TWL were quantitatively measured at 2h pro-injection, 0.5、 1、 2、 4 and 8 h post-injection. Data are presented as mean±S.E. A significant difference was observed between vehicle and SB366791 groups 0.5h after starting TWL evaluations and up to 4h, but 2h after starting MWT evaluations and up to 4h. Statistical analysis was performed using one-way ANOVA followed by the Tukey’s test and p-values <0.05 were regarded as statistically significant. *p<0.05、**p<0.01 VS vehicle group. #p<0.05、 ##p<0.01 VS CCI group. +p<0.01、++p<0.05 VS sham group (n=8).