CeeTox Analysis of J-147.

Figure 2: Effects of J-147 on cellular toxicity, oxidative stress and apoptosis following incubation of rat hepatoma derived H4IIE cells with the drug. Data is expressed as % control for cell mass (blue line), membrane toxicity (black line open square), MTT assay (red line), ATP (purple line), GSH content (green line) or pg/ml for 8-isoprostane. J-147 produced a significant decreases in cell proliferation between 20-100 μM, and both GSH and MTT were affected with TC50 values >200 μM.