CeeTox Analysis of J-147: Oxidative Stress & Apoptosis A) Oxidative Stress B) Apoptosis

Figure 3: Effects of J-147 on (A) oxidative stress (8-isoprostane and GSH) and (B) apoptosis (caspase-3) following incubation of rat hepatoma derived H4IIE cells with the drug. Data is expressed as % control for isoprostane (black line), GSH (green line), and caspase 3 (blue line). J-147 produced a significant decrease in GSH with a TC50 value of 217 μM.