Alpha3/Alpha2   High Middle Low p Demographic  and clinical futures Number of subjects 18 38 18 --- Age, years 70.4 ± 6.7 [60-85] 68.4 ± 8.2 [52-83] 70.4 ± 7.4 [57-80] .55 Sex, female 13 (%) 24 (%) 14 (%) .51 Education, years 6.6 ± 3.6 [4-18] 7.6 ± 3.7 [3-17] 8.3 ± 4.7 [3-18] .42 Mini Mental  State Exam 27 ± 1.7 [23-29] 27.4 ± 1.3 [24-30] 26.9 ± 1.2 [23-30] .46 WMHs (mm3) 2.78 ± 2.58 5.59 ± 6.60 2.57 ± 2.76 .09 Alpha3/alpha2 1.29 ± 0.1 [1.17-1.52] 1.08 ± 0.0 [1-1.16] 0.9 ± 0.1 [0.77-0.98] .000

Table 1: Demographic and cognitive characteristics in the whole sample, disaggregated for increased levels of Alpha3/ Alpha2 Numbers denote mean ± standard deviation, number and [range]. p denotes significance on ANOVA.