Figure 4: (A) Representative image of subconjunctival injections of fluorescent PLGA microparticles two weeks post-injection. Note dispersion of particles along the subconjunctival space. (B) Representative digital images of corneas used to score Oregon Green Dextran-488 (OGD) permeability in nonstressed control mice (NS) and mice subjected to desiccating for 5 days (DS5) and DS5 treated with either Sham-PLGA (DS5+Sham PLGA) or Doxycycline- PLGA (DS5+Doxycycline-PLGA). Sham-PLGA microparticles treatment demonstrates similar results to nonstressed controls, while doxycyclineloaded PLGA microparticles demonstrate efficacy in mitigating desiccating stress. (C) OGD corneal staining score of mice before (NS) and after 5 days of desiccating stress (DS5) and DS5 treated with either Sham-PLGA (DS5+SPLGA) or Doxycycline-PLGA (DS5+D-PLGA). * = P < 0.05 vs. DS5+S-PLGA.