A B & D

>70 yrs old vs <57 yrs Old

>25 μm drusen vs <25 μm drusen

>57 yrs old: >4 μm drusen vs. <4 μm drusen

>63 μm drusen vs <63 μm drusen

IL-1

 Retina * - - *
RPE - - - -
BM * * - *
Ch * * - *
Drusen * NA NA -

RSAD2

 Retina - - * -
RPE - - - -
BM - * - -
Ch - * - -
Drusen - NA NA -

p-STAT3

 Retina *( GCL/INL/ONL) *(GCL/INL/ONL) * *(GCL/INL)
RPE - - - -
BM - - - *
Ch - - - -
Drusen - NA NA -


CXCL-10

Retina * (GCL) * - -
RPE - - - -
BM - - - -
Ch - - * -
Drusen - - - -

CXCL-11

Retina * (OPL) - * <*
RPE - - * -
BM * - * -
Ch - - * -
Drusen - NA NA -

CFI

 Retina

-

 - - -
RPE - - - -
BM - - - -
Ch - - - -
Drusen - NA NA -
Table 3: Semiquantitative analysis of IL-1β, CFI, RSAD2, STAT3, and CXCL-11immunoreactivity. Mann-Whitney test (one-tail unequal variance) with significance set at p≤ 0.05 (black asterisk). Arrowhead denotes population with stronger immunolabeling.