| |
MARINA [7] |
ANCHOR [8] |
PrONTO |
Gupta et al.[14] |
CATT [15] |
Current Study |
| Treatment regimen |
Monthly |
Monthly |
3+PRN |
3+PRN |
1+PRN |
monthly |
1+PRN |
3+PRN |
1+PRN |
| No. injections at 12 months |
12 |
12 |
5.6 |
6 |
4.5 |
11.7 |
6.9 |
4.83 |
3.52 |
| Mean letters* improved at 12 months |
7.2 |
11.3 |
9.3 |
4.4 |
4.1 |
8.5 |
6.8 |
9.5** |
8.0** |
| Eyes losing fewer than 15 letters |
94.6 |
96.4 |
95.0 |
89.4 |
93.5 |
94.0 |
95.0 |
90.1 |
95.2 |
| Eyes gaining 15 letters or more |
33.8 |
40.3 |
35.0 |
52.4 |
48.5 |
34.0 |
25.0 |
54.5 |
28.7 |
* Measured by Early Treatment of Diabetic Retinopathy Study (ETDRS) chart
** Letters on the ETDRS chart calculated a letter equivalent to -0.02 of logMAR equivalent |
