Formula code

Polymer

Plasticizer

Solvent

F1

Hydroxypropyl cellulose (HPC) (10%w/w)

Triethyl citrate(15% w/w)

Distilled water

 

F2

Hydroxypropyl cellulose (HPC) (10%w/w) Eudragit RL100 (2%w/w) (15:1)

Triethyl citrate(15% w/w)

Distilled water

Isopropyl alcohol

F3

Hydroxypropyl cellulose (HPC) (10%w/w) Eudragit RL100 (2%w/w) (5:1)

Triethyl citrate(15% w/w)

Distilled water

Isopropyl alcohol

F4

Hydroxypropyl cellulose (HPC) (10%w/w) Eudragit RL100 (2%w/w) (2:1)

Triethyl citrate(15% w/w)

Distilled water

Isopropyl alcohol

F5

Methyl cellulose(5%w/w)

Triethyl citrate(20%w/w)

Distilled water

F6

Methyl cellulose(5%w/w) Eudragit RL100 (5%w/w) (3:1)

Triethyl citrate(20%w/w)

Distilled water Isopropyl alcohol

F7

Methyl cellulose(5%w/w) Eudragit RL100 (5%w/w) (1:1)

Triethyl citrate(20%w/w)

Distilled water Isopropyl alcohol

F8

Methyl cellulose(5%w/w) Eudragit RL100 (5%w/w) (1:3)

Triethyl citrate(20%w/w)

Distilled water Isopropyl alcohol

F9

Eudragit RL100 (2%w/w)

Triethyl citrate(10% w/w)

Isopropyl alcohol

F10

Eudragit RL100 (5%w/w)

Triethyl citrate(10% w/w)

Isopropyl alcohol

F11

Eudragit RS100 (5%w/w)

Polyethylene glycol 600 (10%w/w)

Acetone/Isopropylalcohol (4:1)

F12

Hydroxypropyl cellulose (HPC) (10%w/w) Ethylcellulose(2%w/w) (15:1)

Triethyl citrate(30%w/w)

Methanol/Methylene chloride(1:1) Methanol/Methylene chloride(1:1)

F13

Hydroxypropyl cellulose (HPC) (10%w/w) Ethylcellulose(2%w/w) (5:1)

Triethyl citrate(30%w/w)

Methanol/Methylene chloride(1:1) Methanol/Methylene chloride(1:1)

F14

Ethylcellulose(2%w/w)

Glycerin (5% w/w)

Isopropyl alcohol

F15

Polyvinyl pyrrolidone K90 (10%)

Polyethylene glycol 600 (25%w/w)

Ethyl alcohol

F16

Polyvinyl pyrrolidone K90 (10%) Eudragit RS100 (5%w/w) (6:1)

Polyethylene glycol 600 (25%w/w)

Ethyl alcohol Acetone/Isopropyl alcohol (4:1)

F17

Polyvinyl pyrrolidone K90 (10% w/w) Eudragit RS100 (5%w/w) (2:1)

Polyethylene glycol 600 (25%w/w)

Ethyl alcohol Acetone/Isopropyl alcohol (4:1)

F18

Polyvinyl pyrrolidone K90 (10% w/w) Eudragit RL100 (5%w/w) (6:1)

Polyethylene glycol 600 (15%w/w)

Ethyl alcohol

Isopropyl alcohol

F19

Polyvinyl pyrrolidone K90 (10% w/w) Eudragit RL100 (5%w/w) (2:1)

Polyethylene glycol 600 (15%w/w)

Ethyl alcohol

Isopropyl alcohol

Table 1: Composition of ocular inserts containing Timolol maleate (300 μg).