Layer Index Healthy DM MDR
Across All Macular Regions      
RNFL 12.38 ± 1.36  11.59 ± 1.19 † (-13%)10.81 ± 1.38 ‡
GCL+IPL 13.81 ± 2.10 (-16%)12.98 ± 1.79 ‡ (-21%)10.96 ± 1.87 ‡
INL 4.36 ± 0.84 (-15%)4.40 ± 0.78 ‡ (-14%)3.74 ± 0.69 ‡
OPL 6.28 ± 1.25 (-23%)6.20 ± 1.48 ‡ (-24%)4.75 ± 0.74 ‡
ONL+IS 7.59 ± 1.58 7.22 ± 1.22 † 6.52 ± 1.48 †
OS 6.09 ± 0.77 (-17%)6.42 ± 0.61 ‡ (-13%)5.32 ± 0.49 ‡
RPE 6.26 ± 0.52 6.61 ± 0.53 † 6.19 ± 0.43
Foveal Region      
RNFL 7.27 ± 0.93 7.03 ± 1.07 † (-12%)6.43 ± 1.13 ‡
GCL+IPL 14.93 ± 2.50 (-24%)13.98 ± 2.93 ‡ (-29%)10.66 ± 2.01 ‡
INL 4.42 ± 0.95 (-17%)4.64 ± 1.02 ‡ 3.87 ± 0.71 †
OPL 8.95 ± 2.04 (-35%)8.72 ± 3.15 ‡ (-36%)5.71 ± 1.40 ‡
ONL+IS 8.55 ± 1.85 8.23 ± 1.48 † 7.28 ± 1.94 †
OS 6.37 ± 0.99 (-17%)6.62 ± 0.68 ‡ (-14%)5.51 ± 0.60 ‡
RPE 6.48 ± 0.63 6.85 ± 0.60 † 6.48 ± 0.52
Parafoveal Region      
RNFL 9.84 ± 1.05 (-11%)9.62 ± 1.00 ‡ (-13%)8.57 ± 1.23 ‡
GCL+IPL 16.11 ± 2.53 (-17%)15.55 ± 2.12 ‡ (-19%)12.97 ± 2.33 ‡
INL 4.75 ± 0.96 (-16%)4.82 ± 0.87 ‡ (-15%)4.04 ± 0.75 ‡
OPL 5.96 ± 1.26 (-17%)6.15 ± 1.25 ‡ (-14%)5.11 ± 0.86 ‡
ONL+IS 7.75 ± 1.62 7.27 ± 1.19 † (-14%)6.66 ± 1.32 ‡
OS 6.02 ± 1.00 (-21%)6.52 ± 0.74 ‡ (-14%)5.18 ± 0.71 ‡
RPE 5.79 ± 0.64 6.32 ± 0.69 † 5.91 ± 0.68
Perifoveal Region      
RNFL 14.02 ± 1.69 (-8%)13.27 ± 1.39 ‡ (-13%)12.16 ± 1.68 ‡
GCL+IPL 12.56 ± 1.96 11.66 ± 1.61 † (-17%)10.46 ± 2.01 ‡
INL 4.19 ± 0.80 (-13%)4.15 ± 0.72 ‡ (-14%)3.59 ± 0.74 ‡
OPL 4.87 ± 0.94 (-14%)4.79 ± 0.79 ‡ (-16%)4.11 ± 0.74 ‡
ONL+IS 6.79 ± 1.42 6.41 ± 1.12 5.92 ± 1.36 †
OS 5.88 ± 0.75 (-18%)6.28 ± 0.71 ‡ (-12%)5.16 ± 0.61 ‡
RPE 6.07 ± 0.55 6.34 ± 0.64 † 5.94 ± 0.54
†0.001<p<0.05 and ‡ p<0.001 (ANOVA followed by Newman-Keuls post hoc analysis). For comparisons between MDR and healthy eyes (see MDR column); and between MDR and DM eyes (see DM column). Changes in percentage are indicated at the upper left of each measure. SD: Standard Deviation; MDR: Mild Diabetic Retinopathy; DM: Diabetes Mellitus
Table 3: Distribution statistics of the layer index (arbitrary units) by study group.