Chernoby liquidators |
Worgul et al. 2007 [12] |
Number of subjects |
8607 |
Mean age at exposure |
32.7 years |
Mean age at eye examination |
44.9 years then 47 years |
Time lag since exposure |
12 and 14 years |
Median eye lens dose |
123 mGy (94%<400 mGy) |
Results |
OR/1Gy=1.70 (1.22-2.38) (any type)
OR/1Gy=1.42 (PSC)
Not significant for CC
Increased risk above 0.5 Gy
Threshold: 0.34 to 0.5 Gy according to the type, maximum 0.7 Gy |
Astronauts |
Cucinotta at al. 2001 [23] |
Chylack et al. 2009 [25] |
Rastegar et al. 2005 [24] |
Number of subjects |
295 |
171 (control group=247) |
21 (control group=395) |
Eye lens dose |
0.2-91 mSv |
15.1-129.3 mSv |
- |
Results |
HR=3.73 (p=0.012) high doses
Vs. low doses for PSC, NC or mixed at 60 yrs.
HR=3.44 for NC alone at 65 yrs. |
Significant increase of CC (p=0.015)
|
OR=3.02 (1.44-6.35) for NC |
Airline pilots |
Rafnsson et al. 2005 [26] |
Number of subjects |
79 pilots; 366 non pilots |
Cumulated dose |
0 - 48 mSv |
Results |
Association with NC, not with tobacco or UVB; no eye lens dose; doses>50 years not considered |
Radiology technicians |
Chodick et al. 2008 [27] |
Number of subjects |
35,705 |
Mean age at exposure |
24-44 years at inclusion |
Mean age at eye examination |
Followed for 20 years |
Median eye lens dose |
28.1 mGy |
Results |
ERR/1Gy=1.98 (ns)
HR high doses (60mGy) vs. low doses (5mGy) =1.18 (0.99-1.4) |
Interventional cardiologists |
Vano et al. 2010 [29] |
Ciraj-Bjelac et al. 2010 [30] |
Number of subjects |
58 IC; 93 NE |
56 IC; 22 NE |
Mean age at eye examination |
IC=46 years; NE=41 years |
IC=42 years; NE=44 years |
Range eye lens dose |
0.1-27 Gy |
0.02-43 Gy |
Results |
OR for PSC=3.2 (38%vs 12%) |
OR for PSC=5.7 (52% vs. 9%) |
