Figure 3: The Interferon Signaling Pathway identified by Ingenuity software. This is one of the canonical pathways that contain statistically significantly more genes than expected by chance in the group of 41-up and 18-down regulated RPE genes in response to AGEs stimulation in vitro. Red symbols represent the genes from our stimulation study, while the white symbols represent genes inserted by Ingenuity to connect relevant molecules into a single pathway.