| Animal group |
Lesion assessment |
Honey treated group |
Control group treated with pentostam injection |
| Ulcer size after infection |
-All animals developed typical cutaneous leishmaniasis after 2 weeks of infection. Ulcer size about 2cm |
| Lesion assessment after one week of treatment |
-Lesion appears bright red with healthy granulation
tissue. |
Lesion appears full of pus |
| -Ulcer size started to decrease in size |
-Ulcer size increased in some cases |
| Lesion assessment after 2 weeks of treatmentSide effects of treatment |
-Healing of the ulcer confirmed by disappearance
of amastigote in the smear and formation of healthy
granulation tissue |
-Non –responsive ulcer with amastigote. Lesion appears
with necrotic tissue full of pus |
| -Ulcer was decreased in size |
- No clinical change or progressing was observed |
| Healing duration |
Recovery of the ulcers was achieved after 4 weeks |
Recovery took prolonged time 12-16 weeks |
| Side effects of treatment |
Honey was applied and removed easily from the lesion
without side effects |
Usually treatment with drug for long term has side effects,
and need supportive treatment. |
| Susceptibility to secondary infection |
-Smears appear free of bacterial and fungal infection
as honey acts as strong bactericidal effects |
-Lesion was full of pus due to secondary infection.
Bactericidal agents must be used |
