Figure 2: Phagocytosis of capsulated and non-capsulated meningitis isolates by human phagocytic cell line U937. Uptake of highly capsulated serotype 7F pneumococci and the 7F-isolate1Δcps by the macrophage-like U937 cells was analyzed after in vitro infection of 1 x 106 U937 cells with 1 x 107 pneumococci (MOI of 10). Phagocytosis of the non-capsulated mutant was significantly higher as uptake of the wild type strain. Standard deviation was calculated from triplicates from two independent standardized experimental setups.*) p < 0.05.