Stage 1 Stage 2 Stage 3   Local infection Early disseminated disease Chronic infection Incubation time 3 to 30 days weeks to months months to years Diseases •Erythema chronicum migrans •benign lymphocytoma •meningitis* •radiculitis* •cranial nerve paresis* •cardiditis •Lyme-arthritis •encepahlomyelitis •acrodermatitis chronica atrophicans Serology IgM-positive 20-90% 10- 40% 0- 30% Serology IgG-positive up to 50% up to 90% (depends on disease duration) almost 100% * Antibody tests in CSF and antibody index should be performed in suspectedneuroborreliosis

Table 1: Stages of Lyme disease.