Amino acid   Treatment     Significance   ROW SOY SER ROW vs SOY ROW vs SER SOY vs SER SDDM             L-Serine 0.0751 ± 0.0054 0.0960 ± 0.0057 0.379 ± 0.103 N.S. p < 0.01 p < 0.05 D-Serine 0.0220 ± 0.0037 0.0191 ± 0.0012 0.0915 ± 0.0374 N.S. N.S. p = 0.10 L-Glutamate 4.440 ± 0.429 5.765 ± 0.195 4.924 ± 0.403 p < 0.05 N.S. N.S. L-Glutamine 3.494 ± 0.159 5.091 ± 0.248 3.476 ± 0.173 p < 0.0005 N.S. p < 0.005 L-Aspartate 1.813 ± 0.185 2.606 ± 0.113 1.971 ± 0.232 p = 0.07 N.S. N.S. L-Valine 0.0568 ± 0.0086 0.105 ± 0.005 0.0695 ± 0.0092 p < 0.0005 N.S. p < 0.005 L-Leucine 0.0695 ± 0.0094 0.120 ± 0.005 0.0840 ± 0.0110 p < 0.01 N.S. p < 0.05 L-Isoleucine 0.0189 ± 0.0033 0.0351 ± 0.0020 0.0246 ± 0.0039 p < 0.05 N.S. N.S. C57BL/6J             L-Serine 0.367 ± 0.005 0.378 ± 0.010 0.533 ± 0.064 N.S. p < 0.05 p < 0.05 D-Serine 0.140 ± 0.003 0.136 ± 0.003 0.154 ± 0.007 N.S. N.S. p < 0.05 L-Glutamate 3.928 ± 0.429 4.487 ± 0.195 3.835 ± 0.403 p < 0.05 N.S. p < 0.005 L-Glutamine 2.654 ± 0.122 4.267 ± 0.656 2.752 ± 0.226 p = 0.09 N.S. p = 0.09 L-Aspartate 1.344 ± 0.185 1.544 ± 0.113 1.500 ± 0.232 N.S. N.S. N.S. L-Valine 0.0450 ± 0.0018 0.0769 ± 0.0047 0.0469 ± 0.0017 p = 0.0001 N.S. p = 0.001 L-Leucine 0.0671 ± 0.0035 0.0844 ± 0.0028 0.0687 ± 0.0051 p < 0.05 N.S. p < 0.05 L-Isoleucine 0.0177 ± 0.0010 0.0230 ± 0.0009 0.0182 ± 0.0010 p < 0.01 N.S. p < 0.01 Abbreviations: ROW, water filtered by reverse osmotic membrane (control); SER, L-serine; SOY, soy peptides; SDDM, genetic serine-deficiency disease model; N.S., not significant. Values are means ± standard errors (SDDM mice: n = 5 for the ROW group; n = 4 for SOY group; n = 4 for the SER group; C57BL/6J mice: n = 4 for the ROW group; n = 6 for the SOY group; n = 5 for the SER group). Amio acid contents in the tissue are shown in nmol/mg wet tissue.

Table 1: Effects of soy peptide or L-serine ingestion on amino acid concentrations in hippocampi of SDDM and C57BL/6J mice.