Amino acid   Treatment     Significance     ROW SOY SER ROW vs SOY ROW vs SER SOY vs SER SDDM             L-Serine 0.0783 ± 0.0092 0.100 ± 0.022 0.346 ± 0.079 N.S. p < 0.001 p < 0.005 D-Serine 0.0227 ± 0.0043 0.0284 ± 0.0012 0.0814 ± 0.0290 N.S. p < 0.05 p = 0.06 L-Glutamate 4.132 ± 0.136 4.394 ± 0.137 4.276 ± 0.103 N.S. N.S. N.S. L-Glutamine 2.965 ± 0.123 3.808 ± 0.224 3.138 ± 0.196 p < 0.01 N.S. p = 0.05 L-Aspartate 1.934 ± 0.101 2.000 ± 0.121 1.975 ± 0.160 N.S. N.S. N.S. L-Valine 0.0631 ± 0.0032 0.815 ± 0.0032 0.0676 ± 0.0028 p < 0.005 N.S. p < 0.05 L-Leucine 0.0803 ± 0.0042 0.993 ± 0.0036 0.0831 ± 0.0048 p < 0.05 N.S. p < 0.05 L-Isoleucine 0.0223 ± 0.0014 0.0277 ± 0.0012 0.0236 ± 0.0013 p < 0.05 N.S. p = 0.10 C57BL/6J             L-Serine 0.340 ± 0.007 0.344 ± 0.013 0.472 ± 0.049 N.S. p < 0.05 p < 0.05 D-Serine 0.138 ± 0.004 0.132 ± 0.004 0.140 ± 0.005 N.S. N.S. N.S. L-Glutamate 3.609 ± 0.135 4.007 ± 0.132 3.260 ± 0.046 p = 0.06 N.S. p < 0.001 L-Glutamine 2.507 ± 0.126 3.928 ± 0.493 2.525 ± 0.172 p < 0.05 N.S. p < 0.05 L-Aspartate 1.675 ± 0.118 1.891 ± 0.096 1.632 ± 0.057 N.S. N.S. N.S. L-Valine 0.0560 ± 0.0038 0.0840 ± 0.0050 0.0526 ± 0.0023 p = 0.001 N.S. p = 0.0005 L-Leucine 0.0737 ± 0.0053 0.0855 ± 0.0032 0.0688 ± 0.0066 N.S. N.S. p = 0.06 L-Isoleucine 0.0189 ± 0.0011 0.0227 ± 0.0011 0.0173 ± 0.0013 p = 0.08 N.S. p < 0.05 Abbreviations: ROW, water filtered by reverse osmotic membrane (control); SER, L-serine; SOY, soy peptides; SDDM, genetic serine-deficiency disease model; N.S., not significant. Values are means ± standard errors (SDDM mice: n = 5 for the ROW group; n = 4 for SOY group; n = 4 for the SER group; C57BL/6J mice: n = 4 for the ROW group; n = 6 for the SOY group; n = 5 for the SER group). Amio acid contents in the tissue are shown in nmol/mg wet tissue.

Table 2: Effects of soy peptide or L-serine ingestion on amino acid concentrations in cerebral cortices of SDDM and C57BL/6J mice.